Abstract MicroRNA-34 (miR-34) has been reported to be dysregulated in various human cancers and regarded as a tumor suppressive microRNA because of its synergistic effect with the well-known tumor suppressor p53.Along with the application of MRX34, the first tumor-targeted microRNA drug which based on miR-34a mimics, on phase I clinical trial (NCT0
Crouch gait is a prevalent walking abnormality among children with cerebral palsy, characterized by excessive knee and hip flexion during walking.This condition often limits children’s engagement in physical activities and daily life.Current exoskeleton solutions targeting the knee joint in this population are either tethered or bulky, hinde
This article offers a portrait of the Peruvian writer Lorenzo de las Llamosas whose life spanned EDTA the seventeenth and eighteenth centuries.A man of many talents, he put his writing skills to work in several genres such as lyric poetry, prose and drama; he was also an intrepid traveller (he left Peru and HAIR FORMULA travelled around most of Eur
The recruitment dynamics into the fishery of eight species in the Wood Sculpture northwestern Mediterranean Sea was studied on the basis of a monthly length sampling on commercial landings lasting one year (March 1999-February 2000).The results show that three species or groups of species (Mullus barbatus and M.surmuletus, Eledone cirrhosa and Loli
Wetlands are sensitive and valuable ecosystems but today their safety and their sustainability have been harshly influenced by various natural and human factors.Using environmental risk assessment is an important tool in studies of environmental management and recognition and reduction of the potentially harmful environmental factors to achieve sus